Hormone - secreting tumours of the pancreas

Peptide-secreting tumours with special reference to the pancreas.

Diagnosis and management of hypoglycaemia due to pancreatic insulin-secreting neoplasia in a German shepherd dog

A 7-year-old castrated male German shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. Laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. Provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. In exploratory laparotomy a small nodular mass was...

Hormone-secreting tumours of the pancreas.

TABLE 1 Landmarks in the history of the islets of Langerhans 1869 First description of pancreatic islets by Langerhans 1902 First tumour of the islets described by Nicholls 1922 Discovery of insulin by Banting and Best 1923 Discovery of glucagon by Murlin and colleagues 1924 Harris postulates the possibility of insulinoma 1927 Wilder extracts insulin from a malignant pancreatic tumour explored ...

Current perspectives on the pathogenesis of clinically non-functioning pituitary tumours.

Pituitary tumours are classified by the characteristic clinical syndromes that accompany tumour hormone production. All of the constituent hormone-secreting cell types of the anterior pituitary are capable of undergoing neoplastic change, although it is evident from histochemical analysis that adenomas derived from pure, functional lactotrophs, corticotrophs, somatotrophs, gonadotrophs and thyr...

Expression of peptide receptors in human endocrine tumours of the pancreas.

BACKGROUND Gut peptides are known to influence hormone release and growth of endocrine tumours of the pancreas. Although information on somatostatin receptors has been provided recently, little is known on the receptor status of other gastrointestinal hormones in such tumours. AIMS To analyse the spectrum of gut hormone receptors on endocrine tumours of pancreas. SUBJECTS Four types of endo...